Health effects of 1,2,3-trichloropropane
Contents
Introduction
1,2,3-Trichloropropane is a colorless, heavy liquid with a sweet but strong odor. It evaporates almost as fast as water (Health effects of 1,2,3-trichloropropane) does at normal temperatures. Small amounts of 1,2,3-trichloropropane will dissolve in water. 1,2,3-Trichloropropane can dissolve several substances, such as oils and waxes, the way water dissolves salt. For this reason, it has been and may continue to be used as an industrial solvent, paint remover, and cleaner. We do not know exactly how much of it is made or used now, but it may be a large amount. Most of the 1,2,3-trichloropropane is used to make other substances.
In sunlight, 1,2,3-trichloropropane in the air will break down. Most of the 1,2,3-trichloropropane that is released to the air will disappear in a month. In water, half of it will evaporate into the air within hours or several days. Very little of it will stick to the soil at the bottom of rivers, lakes, or ponds, and very little of it will be expected to concentrate in fish or other seafoods. 1,2,3-Trichloropropane will not stick to soil. If it is spilled on to most soils, some will evaporate and some will travel through the soil into the groundwater, where it may stay for a long time. It may slowly change to a simpler form in water and soil by natural biological and chemical processes.
Pathways for 1,2,3-trichloropropane in the environment
If you live near a hazardous waste disposal site in which 1,2,3-trichloropropane is not stored properly, you could be exposed to 1,2,3-trichloropropane from breathing air or drinking water. Because 1,2,3-trichloropropane easily changes into a vapor, you are more likely to be exposed from breathing air than from drinking water. A child playing in this waste disposal site could be exposed by drinking liquids containing 1,2,3-trichloropropane, by eating soil coated with 1,2,3-trichloropropane, or getting this soil or liquid on his or her skin.
You could be exposed to 1,2,3-trichloropropane in other ways that have nothing to do with hazardous waste sites. For example, you may be exposed to higher levels of 1,2,3-trichloropropane if you are using paint- and varnish-removers that contain it; however, some of these products may no longer contain this chemical. If you breathe air near an accidental spill of 1,2,3-trichloropropane, you can be exposed to higher levels of the chemical. Exposure in the workplace may result from spills or other accidents or from normal operations in the workplace.
1,2,3-Trichloropropane is not common in the environment (air, water, and soil), but it has been found in a few rivers, bays, drinking water, groundwater, and hazardous waste sites at low levels. This is because 1,2,3-trichloropropane can enter the environment while it is being made, where it is used to make or to dissolve other substances, or where it is released in the waste that is made during these processes. Although 1,2,3-trichloropropane is usually not found in the environment, disposal at hazardous waste sites in the past, or release during spills and accidents have led to higher levels in nearby water, soil, and groundwater. Although we do not know exactly how much 1,2,3-trichloropropane the general public or workers are exposed to, the information that we have shows that the levels are probably low and exposure probably does not occur often.
Exposure to 1,2,3-trichloropropane
If you were to drink water containing 1,2,3-trichloropropane, most of the chemical would pass into your body from your stomach and intestines within the same day. 1,2,3-Trichloropropane would also pass into your body from your lungs if you were to breathe in air containing it or from your skin if you were to touch it. However, we do not know how quickly or completely 1,2,3-trichloropropane passes into your body from your lungs or skin. 1,2,3-Trichloropropane that enters your body leaves your body almost completely within a few days in your breath, urine, and feces.
Pathways for 1,2,3-trichloropropane in the body
If you were to drink water containing 1,2,3-trichloropropane, most of the chemical would pass into your body from your stomach and intestines within the same day. 1,2,3-Trichloropropane would also pass into your body from your lungs if you were to breathe in air containing it or from your skin if you were to touch it. However, we do not know how quickly or completely 1,2,3-trichloropropane passes into your body from your lungs or skin. 1,2,3-Trichloropropane that enters your body leaves your body almost completely within a few days in your breath, urine, and feces.
Health effects of 1,2,3-trichloropropane
Some people who breathed air containing high levels of 1,2,3-trichloropropane for several minutes had eye and throat irritation. These levels of 1,2,3-trichloropropane are likely to be much higher than levels usually found in outdoor air, including air at hazardous waste sites. We do not know what effects might occur in people who breathe 1,2,3-trichloropropane for days, weeks, or longer durations. We also do not know the possible effects of 1,2,3-trichloropropane in people who swallow 1,2,3-trichloropropane or get 1,2,3-trichloropropane on their skin.
Animals that breathed air containing 1,2,3-trichloropropane at levels higher than those usually found in the environment developed other health effects. Rats and mice died after they breathed air containing high levels of 1,2,3-trichloropropane for several hours, but we do not know the exact cause of death. These levels of 1,2,3-trichloropropane are several times higher than those that can cause eye and throat irritation in humans. Rats that breathed 1,2,3-trichloropropane for a few months at levels lower than those that affected humans developed eye, nose, and lung irritation and liver and kidney disease.
Rats and mice usually died from damage to the liver and kidney within a few days after they swallowed a large amount of 1,2,3-trichloropropane. Most rats and mice that swallowed small amounts of 1,2,3-trichloropropane every day for a few months also died from liver and kidney damage. Rats that swallowed even smaller amounts of 1,2,3-trichloropropane every day for a few months did not die but developed stomach irritation, blood disorders, and minor liver and kidney damage.
Rabbits had severe skin irritation and even injury to internal organs, including the liver, kidneys, and stomach after 1,2,3-trichloropropane was applied to their skin in large amounts for 1 day. These injuries can result in death. 1,2,3-Trichloropropane also caused eye irritation in rabbits and rats when it was applied to the eyes.
We do not know if exposure of animals to very small amounts of 1,2,3-trichloropropane by breathing, swallowing, or skin contact for many months or years leads to serious disease or death. Rats that breathed low levels of 1,2,3-trichloropropane for several weeks or swallowed large amounts of 1,2,3-trichloropropane for a few days did not develop fertility problems, but we do not know whether breathing high levels of 1,2,3-trichloropropane or swallowing 1,2,3-trichloropropane for more than a few days affects fertility in animals. 1,2,3-Trichloropropane has not been found to cause birth defects when injected in rats. We do not know whether 1,2,3-trichloropropane causes cancer in humans, but animals that swallowed low doses of 1,2,3-trichloropropane for most of their lives developed cancer in a number of organs.
Medical tests for exposure to 1,2,3-trichloropropane
Scientists can measure 1,2,3-trichloropropane in blood, urine, and breath, but there are no readily available tests to determine whether you have been exposed. We do not think these tests would be adequate to allow doctors to predict harmful health effects.
Further Reading
- The Agency for Toxic Substances and Disease Registry
- Interagency Coordinating Committee on the Validation of Alternative Methods
- European Centre for the Validation of Alternative Methods
- Institute for Laboratory Animal Research
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