Readings are from Berg, Tymockzko, Gatto, and Stryer Biochemistry (8th Edition) OR from Miesfeld & McEvoy Biochemistry. Read one or the other. There is no need to read both.
[BTGS] = Berg, Jeremy M., John L. Tymoczko, Gregory J. Gatto, and Lubert Stryer. Biochemistry. 8th ed. W. H. Freeman & Co., 2015. ISBN: 9781464126109.
[MM] = Miesfeld, Roger L., and Megan M. McEvoy. Biochemistry. W. W. Norton & Company, 2017. ISBN: 9780393614022.
| lec # | topic | readings | |
|---|---|---|---|
Part I: Biomolecules, Methods, and Mechanisms (Lectures by Prof. Michael B. Yaffe) | |||
1 | Introduction; Classes of Biomolecules; pH, Buffers, and Titration Curves | [BTGS] pp. 1–4, 13–17, 22–23 (Appendix 1) or [MM] pp. 3–17, 56–60, 71–78 | |
2 | Amino Acids and Proteins | [BTGS] pp. 27–39, 57–59 or [MM] pp. 11–12, 147–168 | |
| 3 | Protein Purification I | [BTGS] pp. 65–84, 92–95 or [MM] pp. 210–226 | |
4 | Protein Purification II, Protein Structure II | [BTGS] pp. 35–49, 59–62, 85–92 or [MM] pp. 162–193, 227–230 | |
5 | Protein Structure II, Protein Folding | [BTGS] pp. 6–9, 44–60, 169–182 or [MM] pp. 56–67, 193–204, 232–237 | |
| 6 | Hemoglobin and Allostery | [BTGS] pp. 191–212, 286–292, 356–358 or [MM] pp. 259–276 | |
7 | Hemoglobin and the Bohr Effect | [BTGS] pp. 191–212 or [MM] pp. 259–276 | |
8 | Enzyme Chemistry | [BTGS] pp. 215–218, 237–238, 251–264 or [MM] pp. 309–319, 332–336 | |
| 9 | Enzymes as Catalysts | [BTGS] pp. 219–225, 240–241, 299–303 or [MM] pp. 3319–332, 362–363 | |
10 | Enzyme Mechanisms | [BTGS] pp. 264–268 (Carbonic Anhydrase), 455–456 (TPI) or [MM] pp. 326–327 (Carbonic Znhydrase), 455–457 (TPI) | |
11 | Enzyme Kinetics | [BTGS] pp. 225–236 or [MM] pp. 341–356 | |
12 | Carbohydrates/Introduction to Membranes (Lecture by Prof. Matthew Vander Heiden) | [BTGS] Ch. 11.1–11.2 or [MM] Ch. 9.2 | |
13 | Channels, Transporters and Pumps, Protein Modules | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
| 14 | Hormones and Signal Transduction I | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
15 | Receptors, Small G-proteins, and Signal Transduction II | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
16 | Nucleic Acids | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
17 | tRNAs and Protein Translation | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
18 | Translation and the Ribosome | [BTGS] pp. 313–337 or [MM] pp. 632–672 | |
Part II: Metabolism (Lectures by Prof. Matthew Vander Heiden) | |||
19 | Introduction to Metabolism/Polysaccharides/Bioenergetics/Intro Pathways | [BTGS] Ch. 11.1-11.2, 15, 16.1-16.3, 21 or [MM] Ch. 9, 14.2-14.3 | |
20 | Bioenergetics/Intro Pathways/Glycolysis I | [BTGS] Ch. 17 or [MM] Ch. 10 | |
| 21 | Glycolysis II/Regulation | [BTGS] Ch. 17 or [MM] Ch. 10 | |
22 | Glucogenesis/Carbohydrate Storage/TCA Cycle I | [BTGS] Ch. 11.1-11.2, 15, 17, 16.1-16.3, 21 or [MM] Ch. 9, 10, 14.2-14.3 | |
23 | TCA Cycle II | [BTGS] Ch. 17 or [MM] Ch. 10 | |
| 24 | Lipids and Fatty Acid Oxidation | [BTGS] Ch. 12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 | |
25 | Oxidative Phosphorylation | [BTGS] Ch.12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 | |
26 | Oxidative Phosphorylation/Photosynthesis I | [BTGS] Ch. 12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 | |
27 | Photosynthesis II/CO2 Assimilation | [BTGS] Ch. 12.1–12.5, 18, 19, 20.1–20.2, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 | |
| 28 | Pentose Phosphate Pathway | [BTGS] Ch. 19, 20 or [MM] Ch. 14.1 | |
29 | Lipid Synthesis | [BTGS] Ch. 20.3–20.5, 22.4–22.6 or [MM] Ch. 16.2 | |
30 | Nitrogen/Amino Acid Metabolism I | [BTGS] Ch. 23.3–23.5, 24 or [MM] Ch. 17 | |
31 | Amino Acid Metabolism II | [BTGS] Ch. 23.3–23.5, 24 or [MM] Ch. 17 | |
32 | Nucleotide Metabolism | [BTGS] Ch. 25 or [MM] Ch. 18 | |