Calendar

Instructor key:

[MBY] = Prof. Michael B. Yaffe

[MVH] = Prof. Matthew Vander Heiden

lec # topic instructor key dates

Part I: Biomolecules, Methods, and Mechanisms

1

 Introduction; Classes of Biomolecules; pH, Buffers, and Titration Curves MBY Problem set 1 assigned

2

 Amino Acids and Proteins MBY  
3 Protein Purification I MBY

Problem set 1 due

Problem set 2 assigned

4

 Protein Purification II, Protein Structure II MBY  

5

 Protein Structure II, Protein Folding MBY  
6 Hemoglobin and Allostery MBY

Problem set 2 due 

Problem set 3 assigned

7

 Hemoglobin and the Bohr Effect MBY  

8

 Enzyme Chemistry MBY  
9 Enzymes as Catalysts MBY

Problem set 3 due

Problem set 4 assigned

10

 Enzyme Mechanisms MBY  

11

 Enzyme Kinetics MBY Problem set 4 due

Exam 1: Focus on Lectures 1–10  

 Problem set 5 assigned

12

 Carbohydrates/Introduction to Membranes MVH  

13

 Channels, Transporters and Pumps, Protein Modules MBY  
14 Hormones and Signal Transduction I MBY

Problem set 5 due

Problem set 6 assigned

15

 Receptors, Small G-proteins, and Signal Transduction II MBY  

16

 Nucleic Acids MBY  

17

 tRNAs and Protein Translation MBY Problem set 7 assigned

18

 Translation and the Ribosome MBY Problem set 6 due

Exam 2: Focus on Lectures 11–16

Part II: Metabolism

19

 Introduction to Metabolism/Polysaccharides/Bioenergetics/Intro Pathways MVH  

20

 Bioenergetics/Intro Pathways/Glycolysis I MVH  
21 Glycolysis II/Regulation MVH

Problem set 7 due

Problem set 8 assigned

22

 Glucogenesis/Carbohydrate Storage/TCA Cycle I MVH  

23

 TCA Cycle II MVH  
24 Lipids and Fatty Acid Oxidation MVH

Problem set 8 due

Problem set 9 assigned

Exam 3: Focus on Lectures 17–23

25

 Oxidative Phosphorylation MVH Problem set 10 assigned

26

 Oxidative Phosphorylation/Photosynthesis I MVH

Problem set 9 due

27

 Photosynthesis II/CO2 Assimilation MVH  
28 Pentose Phosphate Pathway MVH

Problem set 10 due

Problem set 11 assigned

29

 Lipid Synthesis MVH  

30

 Nitrogen/Amino Acid Metabolism I MVH  

31

 Amino Acid Metabolism II MVH Problem set 11 due

32

 Nucleotide Metabolism MVH  

Exam 4: Focus on lectures 24–32
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