New courses in Biology from MIT OpenCourseWare, provider of free and open MIT course materials. https://ocw.mit.edu/courses/biology 2022-02-11T17:22:16+05:00 MIT OpenCourseWare https://ocw.mit.edu en-US Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm Did you know that we have approximately 2 meters of DNA packed in our cells, which are less than 10 μm diameter? Or that to replicate DNA it is copied at a rate of 70,000 basepairs per second by a cellular apparatus that coordinates at least six different enzymes? Or that microtubules form greater than 1 meter long “railways” upon which molecular machines transport cargo within nerve cells? In this course, we will explore how single-molecule imaging techniques capture the mega-cellular machines working in real-time.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-343-single-molecule-imaging-capturing-nanoscale-cellular-machines-in-action-fall-2021 Fall 2021 Kose, Hazal B. 2022-01-31T21:32:06+05:00 7.343 en-US single-molecule imaging optical tweezers optical traps super-resolution microscopy nanoscopy fluorescence microsscopy smFRET MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm The mammalian immune system is sometimes called a “liquid organ,” capable of rapidly initiating and then resolving potent responses to pathogens at almost any location in the organism. What protein machinery drives immune cells’ rapid migration? How do cells make pathfinding decisions around barriers? How do they find rare pathogens or target cells in complex environments? This course will begin by examining the general immunological functions of two major immune cell types—T cells and dendritic cells. Through our readings and discussions, we will examine the connections between immunotherapy as an emerging treatment modality for a variety of cancers and the migration of immune cells. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-342-immune-cell-migration-on-the-move-in-response-to-pathogens-and-cancer-immunotherapy-fall-2021 Fall 2021 Fessenden, Timothy 2021-12-22T20:01:41+05:00 7.342 en-US immunology T cells dendritic cells immunotherapies immunoediting cell migration cytoskeleton actin integrin adhesions CD103 chemotaxis haptotaxis target cell MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm During Fall 2021, all MIT students and the general public are welcome to join Professors Richard Young and Facundo Batista as they discuss the science of the COVID-19 pandemic. The livestream of the lectures is available to the public, but only registered students are able to ask questions during the Q&A.Lectures will be given by leading experts on the fundamentals of coronavirus and host cell biology, immunology, epidemiology, clinical disease, and vaccine and therapeutic development. Guest faculty include Amy Barczak, Dan Barouch, Arup Chakraborty, Victoria Clark, Shane Crotty, Anthony Fauci, Britt Glaunsinger, Salim Karim, Shiv Pillai, Rochelle Walensky, Bruce Walker, Laura Walker, and Andrew Ward. https://ocw.mit.edu/courses/biology/7-00-covid-19-sars-cov-2-and-the-pandemic-fall-2021 Fall 2021 MIT Department of Biology 2021-09-09T14:27:31+05:00 7.00 en-US COVID-19 SARS-CoV-2 pandemic virology immunology epidemiology vaccines antibodies therapeutics MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm This course focuses on contributions of biochemistry toward an understanding of the structure and functioning of organisms, tissues, and cells. Topics include: Chemistry and functions of constituents of cells and tissues and the chemical and physical-chemical basis for the structures of nucleic acids, proteins, and carbohydrates. Basic enzymology and biochemical reaction mechanisms involved in macromolecular synthesis and degradation, signaling, transport, and movement. General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds. NOTE: The first half of this course, taught by Prof. Yaffe, is available on the MITx platform as 7.05x Biochemistry: Biomolecules, Methods, and Mechanisms. This OCW website provides content primarily from the second half with Prof. Vander Heiden, which focuses on metabolism. https://ocw.mit.edu/courses/biology/7-05-general-biochemistry-spring-2020 Spring 2020 Yaffe, Michael Vander Heiden, Matthew 2021-07-19T15:07:43+05:00 7.05 en-US biochemistry organisms tissues cells metabolism nucleic acids proteins carbohydrates enzymology macromolecules amino acids MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm The natural world is a mega-factory of small molecules, peptides, fatty acids, phospholipids, and a host of other compounds, known as natural products (NPs). Immensely diverse in structure and function, NPs have strongly influenced how we treat infectious disease, cancer, pain, and a host of other conditions. Roughly half of the drugs that have been approved in the past 30 years are NPs, derivatives of NPs or NP-inspired. In this discussion-based course, we will delve into research on discovering NPs from producing organisms, investigating the biochemistry of NP production, and using synthetic biology to create NP derivatives—all with a particular emphasis on how genomic data guides and informs all these studies. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-343-microbial-megaproducers-discovery-biosynthesis-engineering-and-applications-of-natural-products-fall-2020 Fall 2020 Ulrich, Emily Hetrick, Kenton 2021-07-09T17:23:31+05:00 7.343 en-US small molecules peptides fatty acids phospholipids natural products NPs biosynthetic enzymes RiPPs NRP-PKS non-ribosomal peptide NPs metagenomic methods MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm Metastatic disease is responsible for the vast majority of deaths associated with cancer, yet our understanding of how metastases arise is still developing. In this course, we will introduce various concepts and models that have been proposed to explain how cancer cells disseminate from a primary tumor to distant anatomical sites. We’ll learn about the critical factors that influence cancer metastasis frontiers through analysis and discussion of relevant primary research articles, with an emphasis on mechanisms of metastasis that can be applied across different cancer types. Students will gain a broad understanding of the field of cancer metastasis, including state-of-the-art techniques that are being used to address pressing questions in the field.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-342-the-seeds-and-the-soil-roles-of-tumor-heterogeneity-and-the-tumor-microenvironment-in-cancer-metastasis-fall-2020 Fall 2020 Lambert, Arthur Zhang, Yun 2021-03-16T16:23:26+05:00 7.342 en-US cancer metastasis neoplastic cells tumor heterogeneity microenvironment epithelial-mesenchymal transition circulating tumor cells stromal cells cancer stem cells metastatic tropism metastatic niche MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm During Fall 2020, all MIT students and the general public were welcomed to join Professors Richard Young and Facundo Batista as they discussed the science of the pandemic during this new class. The livestream of the lectures was available to the public, but only registered students were able to ask questions during the Q&A. Special guest speakers included: Drs. Anthony Fauci, David Baltimore, James Bradner, Victoria Clark, Kizzmekia Corbett, Britt Glaunsinger, Akiko Iwasaki, Eric Lander, Michael Mina, Michel Nussenzweig, Shiv Pillai, Arlene Sharpe, Skip Virgin, and Bruce Walker.NOTE: This class ran from September 1, 2020 through December 8, 2020.  https://ocw.mit.edu/courses/biology/7-00-covid-19-sars-cov-2-and-the-pandemic-fall-2020 Fall 2020 MIT Department of Biology 2020-09-10T15:53:03+05:00 7.00 en-US COVID-19 SARS-CoV-2 pandemic virology immunology epidemiology vaccines antibodies therapeutics MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm 7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology, and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention. The MIT Biology Department Introductory Biology courses 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. https://ocw.mit.edu/courses/biology/7-016-introductory-biology-fall-2018 Fall 2018 Imperiali, Barbara Martin, Adam Ray, Diviya 2020-05-12T13:01:52+05:00 7.016 en-US biochemistry molecular biology genetics human genetics pedigrees biochemical genetics molecular biology chemical biology molecular genetics recombinant DNA technology cell biology cancer viruses HIV bacteria antibiotics human health therapeutic intervention cell signaling evolution reproduction infectious diseases therapeutics MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm The MIT Biology Department core Introductory Biology courses, 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. The focus of 7.013 is on genomic approaches to human biology, including neuroscience, development, immunology, tissue repair and stem cells, tissue engineering, and infectious and inherited diseases, including cancer. https://ocw.mit.edu/courses/biology/7-013-introductory-biology-spring-2018 Spring 2018 Amon, Angelika Sive, Hazel Ray, Diviya 2019-08-01T17:32:55+05:00 7.013 en-US biology biochemistry genetics molecular biology recombinant DNA cell cycle cell signaling cloning stem cells cancer immunology virology genomics molecular medicine DNA RNA proteins replication transcription mRNA translation ribosome nervous system amino acids polypeptide chain cell biology neurobiology gene regulation protein structure protein synthesis gene structure PCR polymerase chain reaction protein localization endoplasmic reticulum human biology inherited diseases developmental biology evolution human genetics human diseases infectious agents infectious diseases MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm This course will explore the current frontiers of the world of RNA biology with primary research papers to trace how the original odd detail sometimes leads to major discoveries. As we discuss the different transcripts and processing events that enable this exciting diversity of RNA functions, we invite you to read landmark papers with us, think critically, and ask new questions, as we marvel at the wonders of RNA. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-341-dnas-sister-does-all-the-work-the-central-roles-of-rna-in-gene-expression-spring-2019 Spring 2019 Fiszbein, Ana Jens, Marvin 2019-08-01T17:14:16+05:00 7.341 en-US RNA DNA mRNA transfer RNA ribosomal RNA base-pairing splicing small non-coding RNAs microRNAs siRNAs piRNAs long non-coding RNAs circular RNAs chromatin transcriptomes MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm Students will learn about the use of biomaterials to create advanced diagnostic tools for detection of infectious and chronic diseases, restore insulin production to supplement lost pancreatic function in diabetes, provide cells with appropriate physical, mechanical, and biochemical cues to direct tissue regeneration, and enhance the efficacy of cancer immunotherapy.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.  https://ocw.mit.edu/courses/biology/7-341-biomaterials-and-devices-for-disease-diagnosis-and-therapy-fall-2018 Fall 2018 McHugh, Kevin Beyzavi, Ali 2018-12-21T17:49:16+05:00 7.341 en-US biomaterials biocompatibility cell-protein interactions controlled release polymer modification self-assembly diagnostic tools tissue regeneration cancer immunotherapy vaccines therapeutics MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm In this course we will explore how altered metabolism drives cancer progression. Students will learn (1) how to read, discuss, and critically evaluate scientific findings in the primary research literature, (2) how scientists experimentally approach fundamental issues in biology and medicine, (3) how recent findings have challenged the traditional “textbook” understanding of metabolism and given us new insight into cancer, and (4) how a local pharmaceutical company is developing therapeutics to target cancer metabolism in an effort to revolutionize cancer therapy. https://ocw.mit.edu/courses/biology/7-344-cellular-metabolism-and-cancer-nature-or-nurture-fall-2018 Fall 2018 Lau, Allison Lien, Evan 2018-12-17T17:40:12+05:00 7.344 en-US cancer metabolism Warburg effect mitochondrial function tumor cell stroma cell Amino Acid nucleotide lipid genetic change metabolic interaction MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm Immune cells protect our bodies from both self-derived threats and exogenous pathogens, while keeping peace with normal cells and non-harmful commensal microbiota. They have various mechanisms to perform these tasks, a capacity that is essential for maintaining homeostasis. However, these same mechanisms can backfire, resulting in severe disorders such as immunodeficiency, chronic inflammation, allergy, degenerative diseases, and cancer. This course discusses the connections between normal physiology and disease by examining the developmental relationship between innate and adaptive immune cells as well as the functions and malfunctions of immune cells. The course familiarizes students with both basic biological principles (such as cell death and immune cell signaling) and clinical applications (such as immune checkpoint blockade). More generally, students learn to identify relevant primary research literature, critically evaluate experimental data, and reach their own conclusions based on primary data. https://ocw.mit.edu/courses/biology/7-342-a-double-edged-sword-cellular-immunity-in-health-and-disease-fall-2018 Fall 2018 Ma, Haiting 2018-12-07T20:16:50+05:00 7.342 en-US immunodeficiency autoimmune diseases cancer immune surveillance homeostasis immune deficiency cell signaling immune checkpoint blockade hematopoiesis cytotoxicity cell death T cells lymphocytes adoptive immune transfer macrophages trained immunity MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm There are more microbes permanently living in our gut than there are cells in the human body. This rich community of bacteria, fungi and viruses, called the microbiome, plays a central role in human health and disease. Recent research has linked this passenger community to nutrition, circadian rhythms, infectious disease, inflammatory disease, cancer, diabetes, arthritis and even immune system and nervous system development. How can we analyze such a complex system? Can we exploit the microbiome to improve human health? Can interactions with microbes be harnessed for drug delivery? In this course, we will learn to critically assess the primary scientific literature to find answers to these questions and learn to distinguish between correlation and causality. We will learn how mechanistic insights and emerging tools, such as synthetic biology and microfluidics, together are transforming microbiome research, and might lead to new types of therapeutics and drug delivery for improving human health. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-341-the-microbiome-and-drug-delivery-cross-species-communication-in-health-and-disease-spring-2018 Spring 2018 Beyzavi, Ali Jimenez, Miguel 2018-06-26T14:51:28+05:00 7.341 en-US microbiome microbiome signaling human-produced antimicrobial peptides microbial pheromones bacterial peptide toxins neuroactive microbial metabolites microfluidics next-generation DNA sequencing next-generation RNA sequencing germ-free mice synthetic biology synthetic microbes MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm In this course, we will explore how animals determine and maintain cell fate. We will discuss changes to DNA structure and packaging, special proteins (known as "master regulators") with the ability to alter cell fate via transcription, cell-cell signaling, and RNA localization. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-342-how-to-build-an-animal-cell-fate-and-identity-in-development-and-disease-fall-2017 Fall 2017 Blanton, Laura 2018-01-22T21:22:32+05:00 7.342 en-US cell identity cell fate stem cells pluripotent gene expression cell lineages transcriptional networks germ cells transcription factors hematopoietic identities cell signaling MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm Parasites require a hospitable organism to reproduce and spread and have evolved multiple strategies to subvert their hosts. Parasites scavenge nutrients directly from host cells, evade the host immune system and even modify host behavior to increase their transmission. This course will explore the strategies used by a ubiquitous and harmful class of parasites to hijack the biology of their host cells. We will discuss pathogens such as Plasmodium and Toxoplasma, responsible for some of the deadliest and most pervasive infectious diseases on the planet.By exploring how these pathogens invade a host cell and replicate while evading the immune system, students will gain a broad understanding of basic cell biology, biochemistry and immunology, as well as learn techniques commonly used in cell biology. Students will be challenged to think creatively and flexibly to understand, critique, interpret, and design scientific experiments in the field of host-pathogen interactions. https://ocw.mit.edu/courses/biology/7-341-host-hacking-parasitic-manipulations-from-a-micro-to-a-macroscopic-scale-fall-2016 Fall 2016 Harding, Clare Huet, Diego 2017-01-24T18:52:14+05:00 7.341 en-US parasites host Plasmodium Toxoplasma malaria molecular parasitology Toxoplasma gondii Plasmodium falciparum PTEX Theileria PfEMP1 MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm In this course, we will investigate the diverse types and functions of different RNA species, with a focus on "non-coding RNAs," i.e. those that do not directly encode proteins. The course will convey both the exciting discoveries in and frontiers of RNA research that are propelling our understanding of cell biology as well as the intellectual and experimental approaches responsible.The molecular biology revolution firmly established the role of DNA as the primary carrier of genetic information and proteins as the primary effector molecules of the cell. The intermediate between DNA and proteins is RNA, which initially was regarded as the "molecule in the middle" of the central dogma. This view has been transformed over the past two decades, as RNA has become recognized as a critical regulator of cellular processes.   https://ocw.mit.edu/courses/biology/7-342-the-rna-revolution-at-the-frontiers-of-cell-biology-and-molecular-medicine-fall-2016 Fall 2016 Garg, Salil Ward, Amanda 2017-01-09T20:30:28+05:00 7.342 en-US RNA non-coding RNAs ribosomal RNA catalytic RNA circular RNA long non-coding RNA RNAi RNA therapeutics microRNAs CRISPR/Cas9 miRNAs siRNA MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper. https://ocw.mit.edu/courses/biology/7-88j-protein-folding-and-human-disease-spring-2015 Spring 2015 King, Jonathan 2016-04-07T21:43:41+05:00 7.88J 5.48J 10.543J en-US protein folding misfolding aggregation protein structures folding intermediates off-pathway aggregation amyloid formation Key chaperones chaperonins human protein deposition diseases Alzheimer’s disease Parkinson’s disease Huntington’s disease amyloids prions amino acid sequence amyloid polymerization chaperone structure and function folding and assembly of fibrous proteins MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm How do we sense hunger? How do we sense pain? What causes growth in our bodies? How are we protected from pathogens? The answer to many of these questions involves small polymers of amino acids known as peptides. Peptides are broadly used as signal molecules for intercellular communication in prokaryotes, plants, fungi, and animals. Peptide signals in animals include vast numbers of peptide hormones, growth factors and neuropeptides. In this course, we will learn about molecular bases of peptide signaling. In addition, peptides potentially can be used as potent broad-spectrum antibiotics and hence might define novel therapeutic agents. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-347-peptides-as-biological-signaling-molecules-and-novel-drugs-spring-2016 Spring 2016 Shabab, Mohammed 2016-03-24T21:05:05+05:00 7.347 en-US peptides signal molecules intercellular communication peptide hormones growth factors neuropeptides antimicrobial peptides (AMPs) defensins biotic interactions Peptide transporters epidermal growth factors (EGFs) MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm The aim of this class is to introduce the exciting and often under appreciated discoveries in RNA biology by exploring the diversity of RNAs—encompassing classical molecules such as ribosomal RNAs (rRNAs), transfer RNAs (tRNAs) and messenger RNAs (mRNAs) as well as newer species, such as microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). For each new class of RNA, we will evaluate the evidence for its existence as well as for its proposed function. Students will develop both a deep understanding of the field of RNA biology and the ability to critically assess new papers in this fast-paced field.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. https://ocw.mit.edu/courses/biology/7-343-an-rna-safari-exploring-the-surprising-diversity-of-mammalian-transcriptomes-spring-2016 Spring 2016 Pai, Athma Taliaferro, Matthew 2016-03-16T19:38:33+05:00 7.343 en-US RNA ribosomal RNAs (rRNAs) transfer RNAs (tRNAs) messenger RNAs (mRNAs) microRNAs (miRNAs) long-noncoding RNAs (lncRNAs) circular RNAs (circRNAs) high-throughput sequencing snRNAs pre-mRNA splicing snoRNAs regulatory molecules siRNA piRNAs CRISPR-associated RNAs MIT OpenCourseWare https://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm