Sertraline

Sertraline hydrochloride ((1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-nanphthalenamine hydrochloride, C₁₇H₁₇NCl₂·HCl) is a white, sparingly soluble crystalline solid.

Sertraline is used medically to treat the symptoms of depression. It is a selective serotonin reuptake inhibitors and works by blocking the uptake of serotonin into platelets. It is prescribed under the tradename Zoloft® and is manufactured by Pfizer, as white and yellow 50 mg capsules or orange 100 mg capsules. It is used in dosages of between 50 mg and a maximum of 200 mg per day. It has also been prescribed for the treatment of obsessive-compulsive disorder, post-traumatic stress disorder, premenstrual dysphoric mood disorder[?] and panic disorder[?]. It was first approved by the FDA in 1997.

It has a number of adverse effects including insomnia, asthenia, gastrintestinal complaints, tremours, confusion and dizziness, it can induce mania or hypomania in around 0.5% of patients. It is contraindicated in individuals taking MAOIs or undergoing electroconvulsive therapy.

External Link

• http://www.zoloft.com/