Sharpless bishydroxylation is a
chemical reaction of an
alkene with
osmium tetroxide to form an diol (dialcohol).
Chiral products can be formed by adding
quinine derivatives. A more efficient way to perform this reaction is reoxidise the osmate, which is formed in the reaction, with
potassium hexacyanoferrate[?]. This reduces the amount of the highly toxic and very expensive osmium tetroxide needed by up to 95%. It is possible to buy these mixtures as AD-mix α and AD-mix β.
The chiral diols are important for further synthesis. The introduction of chirality into nonchiral reactants through small amounts of a chiral catalyst is an important concept in organic synthesis[?].
K. Barry Sharpless[?] won the 2001 Nobel Prize in Chemistry.