An
integrin, or
integrin receptor, is a
receptor in the
plasma membrane of
biological cells. Integrins play an important role in:
Among the
ligands of integrins are
fibronectin and
collagen, both part of the extracellular matrix. Ligand binding leads to
clustering (cross-connection) of the
multivalent[?] components of the integrin to a functional
protein complex. Integrins have no
intrinsic[?] kinase activity, but associate kinases (for example,
focal adhesion kinase[?],
FAK) on the
cytoplasmic[?] side of the membrane.